Heart Failure with Mildly Reduced Ejection Fraction: An HFSA Scientific Statement
DOI: 10.1016/j.cardfail.2026.01.024
Wilcox JE, Lund LH, Cox ZL, Ho JE, Lam CSP, Sharma K, Borlaug BA. J Card Fail 2026.
Top Take-Home Messages Slide Deck
In addition to reviewing the guidance found within Heart Failure with Mildly Reduced Ejection Fraction, clinicians can use the Top Take-Home Messages slide deck as a quick reference guide. Designed by the statement's lead authors, this slide deck covers everything from recognizing HFmrEF in practice to applying guideline-directed therapy in the absence of dedicated trial data. View the slide deck >>
Coming Soon: Episode of the Heart Failure Beat
Catch up on old episodes of the podcast while the hosts work on the new episode with co-lead authors on the Heart Failure with Mildly Reduced Ejection Fraction: An HFSA Scientific Statement episode. Listen to old episodes >>
Press Release
New HFSA Scientific Statement Provides Practical Framework for Managing Heart Failure with Mildly Reduced Ejection Fraction
WASHINGTON, DC (April 22, 2026) - A new Scientific Statement from the Heart Failure Society of America (HFSA) challenges longstanding ambiguity in the classification and treatment of heart failure with mildly reduced ejection fraction (HFmrEF), emphasizing that it should be recognized as a distinct and clinically meaningful condition, rather than a borderline category.
Published in the Journal of Cardiac Failure, the statement defines HFmrEF as a left ventricular ejection fraction of 41–49% and provides a structured, evidence-based framework to support more consistent recognition, evaluation, and management in clinical practice. Read the full press release >>