Dr. Umapathi was born in Orsett, England and grew up in the United Kingdom, the United States and in India. Her accent is still catching up with all the moving. Running her first DNA gel as a teen hooked her on science and she grew up realizing that engineering translational therapies for HF patients makes her heart sing. Dr. Umapathi completed her internal medicine training at Rutgers, served as chief resident in medicine and did research in the laboratory of Dr. Junichi Sadoshima. She completed her cardiovascular disease, advanced heart failure training at Johns Hopkins and finished her research training in the laboratory of Dr Mark Anderson.  Dr. Umapathi is an Assistant Professor of Medicine at the Johns Hopkins Hospital in the Advanced Heart Failure/Transplant/MCS section. She attends on the in-patient heart failure and transplant cardiology services at the Johns Hopkins Hospital and sees clinic patients at the Johns Hopkins Bayview campus. Dr. Umapathi also heads the CardioMetabolic Heart Failure Clinic at Johns Hopkins. When not seeing patients, or in the lab, she enjoys surprising/horrifying her mother with opportunities for molecular gastronomy-based meals or plotting her next climb. As a physician scientist she leads a basic and translational research program focused on cardiac metabolism and proteins. Her research identifies novel molecular mechanisms, therapeutic targets for heart failure and creating a clinical precision medicine proteomic pipeline. Her clinical - translational interest is in inherited cardiomyopathies, cardio-metabolic HF, cardiac remodeling/energetics and SGLT2 inhibitors.