Device-Based Solutions for HFpEF: Beyond GDMT

This session will explore the evolving role of device-based therapies designed to directly modify HFpEF physiology. Faculty will review the mechanistic rationale and clinical evidence supporting interatrial shunt devices, splanchnic nerve modulation, and cardiac contractility modulation, highlighting lessons learned from recent randomized trials and ongoing studies. Emphasis will be placed on patient selection, phenotyping, and future trial design, with the goal of helping clinicians understand which patients may benefit from device-based interventions and where the field is headed next.

Learning Objectives

• Describe the hemodynamic mechanisms in HFpEF that provide the rationale for device-based therapies.
• Evaluate the current evidence for interatrial shunts, splanchnic nerve modulation, and cardiac contractility modulation in HFpEF.
• Identify patient selection strategies and future directions for device-based interventions in HFpEF.